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There is a philosophical and social movement known as Effective Altruism that advocates "using evidence and reason to figure out how to benefit others as much as possible, and taking action on that basis” [Wikipedia]. I encourage you to read more about this at https://www.effectivealtruism.org/articles/introduction-to-effective-altruism
By donating here you will be making a significant positive difference to people who were not born with our luck. The distribution is managed by a charity called The Life You Can Save who use objective measurements to maximise efficiency to a group of other charities.
Thank you, Eugene.
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