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Max Appeal was founded by parents of children diagnosed with 22q11/DiGeorge Syndrome/VCFS (remove 22q11 deletion syndrome). They are a small national charity, run almost exclusively by a group of dedicated volunteers backed up with a knowledgeable panel of medical professionals. Max, who was the inspiration for the charity's beginning had a short life but Max Appeal is a charity with a vibrant life of its own.

22q11.2 is like a post code that tells medics that 40 or so genes are missing or duplicated from the long arm of the 22nd chromosome, this is also the underlying cause of DiGeorge syndrome and VCFS. The effect 22q11 Deletion Syndrome (and Duplication Syndrome) has is unique to every individual, from fatal heart defects, catastrophic immune deficiency and severe learning disabilities, to mild behavioural problems, speech and language issues and facial characteristics. It is a multi-system disorder and the greatest known generic risk factor to schizophrenia.

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