What is IgA nephropathy? IgA nephropathy (IgAN) is a kidney disease that commonly appears for the first time in young adults and can lead to kidney failure with the requirement for lifelong dialysis or a kidney transplant. Worldwide IgAN is a common cause of kidney failure and it is estimated that globally 1 in 10 patients who need dialysis treatment have kidney failure because of IgAN. At present, there is no effective treatment for IgAN and while a kidney transplant can transform the lives of IgAN patients who are on dialysis there is the risk that the IgAN may recur in the transplant and lead to loss of the transplant. The Leicester IgA Nephropathy Research Group This is a partnership between the University of Leicester and University Hospitals of Leicester NHS Trust. The Group has been established for over 25 years and works closely with patients, charities, including Kidney Research UK, and the pharmaceutical industry.