My friend Nathan and I will be cycling the Land's End to John o' Groats route on Sunday 18th September to raise money and awareness for Zellweger UK.

Zellweger Spectrum Disorder has had a significant impact on my family, whilst the condition is awful, Harry has brought us untold joy.

Children and families experiencing this condition have daily uphill struggles, for that reason Nathan and I will be undertaking the roughly 900 mile trip, unaided and carrying kit in order to camp for the duration of the route.

Peroxisomal Disorder on the Zellweger Spectrum (also sometimes referred to as Generalized Peroxisomal Disorder) is categorised by the absence of peroxisomes. Peroxisomes are cell structures that break down toxic substances and synthesize lipids (fatty acids, oils, and waxes) that are necessary for cell function. Peroxisomes are required for normal brain development and function as well as the formation of myelin, the substance that coats nerve fibres in the brain.

ZSD affects an estimated 1/50,000 live births. Children usually don’t live long into adulthood, however the spectrum is wide and life expectancy ranges from days old to patients who live into their 30s. Most children have some degree of facial characteristics such as a broad nasal bridge, low set ears, a large fontanelle (soft spot) and a high forehead (which in our humble opinion makes for incredibly beautiful children!) they also usually have shortened limbs to some degree and small hands and feet.

All donations go directly to Zellweger UK.

https://www.zellweger.org.uk/