The course covers all five boroughs of New York City. It begins on Staten Island near the approach to the Verrazano-Narrows Bridge. The bridge, which normally carries only vehicular traffic, is closed for the event. Runners use both sides of the upper level of the bridge and the westbound side of the lower level. In the opening minutes of the race, the bridge is filled with runners, creating a dramatic spectacle that is closely associated with the event.

After descending the bridge, the course winds through Brooklyn for approximately the next eleven miles. Runners pass through an enormous variety of neighborhoods, including: Bay Ridge, Sunset Park, Bedford-Stuyvesant, Williamsburg, and Greenpoint. At 13.1 miles, runners cross the Pulaski Bridge, marking the halfway point of the race and the entrance into Queens. After about two and a half miles in Queens, runners cross the East River on the Queensboro Bridge into Manhattan. It is at this point in the race when many runners begin to tire, as the climb up the bridge is considered one of the most difficult points in the marathon.

Finally reaching Manhattan after about 16 miles, the race proceeds north on First Avenue, then crosses briefly into The Bronx via the Willis Avenue Bridge for a mile before returning to Manhattan via the Madison Avenue Bridge. It then proceeds south through Harlem down Fifth Avenue and into Central Park. At the southern end of the park, the race proceeds across Central Park South, where thousands of spectators cheer runners on during the last mile. At Columbus Circle, the race re-enters the park and finishes outside Tavern on the Green. The time limit for this course is 8 1/2 hours from the 10:10 a.m. start. (We hope to be finished within that time).