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I happened to recently attend a business networking meeting at the Positive East building on Mile End Road, part of which we had a tour and talk on the work they do, which is awe inspiring.
Have a look at their youtube channel here: https://www.youtube.com/channel/UCK6WAap9RITLk-75QsABjkg too. Anything you can do to help would be great.
I often get asked 'why should I sponsor someone for something they would do and enjoy anyway'. Running a marathon is NOT fun. It is absolutely brutal. Up to 800 miles need to be run in advance of the day to build the fitness levels needed to run a marathon.
To know that you need to complete this in order to raise money for such a good cause is a huge psycological benefit when you are in the 20+ mile zone with every part of your body telling you to stop.